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Fig. 3 | Respiratory Research

Fig. 3

From: Activation of the nicotinamide N-methyltransferase (NNMT)-1-methylnicotinamide (MNA) pathway in pulmonary hypertension

Fig. 3

Changes in NNMT pathway in MCT-induced pulmonary hypertension. a Increase in NNMT activity in the lungs at 2 and 4 weeks post MCT (n = 4 in each group). b Increase in NNMT immunofluorescence in the lungs at 4 weeks post MCT (n = 3 in each group). c Increase in NNMT liver activity and d immunointensity at 4 weeks post-MCT (n = 4 in each group). e Increase in plasma MNA concentration at 4 weeks post MCT (Control n = 5, 2 weeks post-MCT n = 6, 4 weeks post-MCT n = 9). f Increase in Met2PY concentration at 4 weeks post MCT (Control n = 5, 2 weeks post-MCT n = 6, 4 weeks post-MCT n = 9). Data are presented as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001

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