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Fig. 2 | Respiratory Research

Fig. 2

From: Activation of the nicotinamide N-methyltransferase (NNMT)-1-methylnicotinamide (MNA) pathway in pulmonary hypertension

Fig. 2

NO- and PGI2-dependent function in the isolated lung in PAH and systemic prostacyclin production. a Progressive impairment of L-NAME-induced effect on the magnitude of hypoxic pulmonary vasoconstriction (HPV) in isolated blood-perfused lungs 1-4 weeks post-MCT, with no changes in basal HPV; hypoxic ventilation with 5 % CO2 + 95 % N2 (Control n = 8, 2 weeks post-MCT n = 6, 4 weeks post-MCT n = 9); ΔPAP – the change in Pulmonary Arterial Pressure. b Lack of changes of 6-keto-PGF concentration followed by a compensatory increase in 6-keto-PGF in the effluents of isolated Krebs-Henseleit-perfused lungs at 2 and 4 weeks post-MCT, respectively (Control n = 15, 2 weeks post-MCT n = 12, 4 weeks post-MCT n = 16). c Changes in 6-keto-PGF concentration: increased 6-keto-PGF in plasma 4 weeks post MCT (Control n = 15, 2 and 4 weeks post-MCT n = 15). d Changes in ET-1 concentration in plasma of rats treated with MCT: increase at 2 and 4 weeks post MCT (Control n = 11, 2 weeks post-MCT n = 12, 4 weeks post-MCT n = 18). Data are presented as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001

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