Table 3 Univariate analysis

Gender

[male versus female]

1.213

0.59–2.48

0.596

1.152

0.67–1.96

0.602

1.063

0.70–1.60

0.770

Age

[≤66 versus >66 years]

1.709

0.82–3.55

0.151

1.153

0.68–1.94

0.592

1.191

0.79–1.77

0.390

Smoking status

[never versus current/former]

1.478

0.60–1.47

0.395

1.782

0.85 - 3.69

0.121

1.332

0.79–2.23

0.278

Comorbidity

[no versus yes]

1.395

0.65–2.96

0.388

-

-

-

-

-

-

ALK-CNG^a

[Disomic/3-7 versus > 7]

1.695

0.49–5.77

0.399

1.498

0.62–3.57

0.363

1.598

0.85–2.98

0.141

Disease stage

[I-II versus III]

13.12

4.59–37.4

<0.001

-

-

-

-

-

-

T descriptor

[1–2 versus 3–4]

3.920

1.73–8.86

0.001

-

-

-

-

-

-

N descriptor

[0 versus 1]

4.259

1.79–10.2

0.001

-

-

-

-

-

-

Grading

[1 versus 2 versus 3]

2.128

3.390

0.42–10.6

0.73–15.6

0.357

0.117

-

-

-

-

-

-

Surgery

[yes versus no]

8.425

3.65–19.3

<0.001

-

-

-

-

-

-

Performance Status

[0 versus 1 versus 2–3]

-

-

-

2.358

4.581

1.25–4.42

1.81–11.5

0.007

0.001

1.647

3.864

1.00–2.70

1.98–7.52

0.049

<0.001

Synchronous Metastases

[no versus yes]

-

-

-

1.119

0.15–8.14

0.912

2.335

1.52–3.58

<0.001

Response rate to 1st line

[yes versus no]

-

-

-

-

-

-

2.356

1.31–4.23

0.004