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Fig. 6 | Respiratory Research

Fig. 6

From: Metformin attenuates lung fibrosis development via NOX4 suppression

Fig. 6

Hypothetical model of metformin-mediated inhibition of myofibroblast differentiation. Metformin-mediated AMPK activation is responsible for inhibiting NOX4 expression and ROS production, which is at least partly involved in the mechanisms for attenuation of TGF-β-induced SMAD phosphorylation and myofibroblast differentiation in relation to fibroblastic foci formation in IPF pathogenesis

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