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Fig. 5 | Respiratory Research

Fig. 5

From: Induction of pulmonary antibodies against oxidized lipids in mice exposed to cigarette smoke

Fig. 5

The proportion of pulmonary macrophages with intracellular particles increases over the course of cigarette smoke exposure. Female 6–8 week old BALB/c mice were exposed to room air (RA) or cigarette smoke (CS) for 1 h, twice a day, 5 days a week for 4 days, 8 weeks, or 24 weeks, and followed by cessation periods. a Lungs were subjected to bronchoalveolar lavage (BAL), total cells counted, and cell differentials performed to determined the absolute number of mononuclear cells in the BAL. b Black particles were counted in pulmonary macrophages and expressed as the absolute number of macrophages with intracellular particles. The dashed red line represents the highest number of pulmonary macrophage with internalized particles observed in a room air exposed mouse (particle background). Data represent mean ± SEM; n = 4–5/group; *p < 0.05

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