Skip to main content

Table 2 Circulating biomarkers grouped according to DanaPoint classification

From: The role of circulating thrombospondin-1 in patients with precapillary pulmonary hypertension

 

Control

All PH

PAH

LD

CTEPH

TSP-1 [ng/mL]

82.1 ± 15.8

1114* ±136

1025* ±161

799* ± 237

1852*,**,*** ±428

bigET [pg/mL]

1.22 ± 0.34

2.96* ±0.34

3.05* ±0.48

2.29 ± 0.53

4.06* ±0.75

PDGF-ββ [pg/mL]

152 ± 11

784* ±161

905 ± 253

652* ±145

382 ± 173

PF4 [pg/mL]

2.12 ± 0.25

3.05(*) ±0.29

2.81 ± 0.30

3.60 ± 0.72

2.95 ± 0.86

SDF-1α [pg/mL]

71.6 ± 8.7

124.5* ±14.2

128 ± 21.4

121 ± 17.1

116 ± 46.1

NT-proBNP [pg/mL]

128.0 ± 49

1212* ±214

1070* ±213

1529 ± 662

1296* ±495

Creatinine [mg/dL]

0.77 ± 0.22

1.01 ± 0.32*

1.06 ± 0.32*

0.95 ± 0.26

0.94 ± 0.35

Uric acid [mg/dL]

5.09 ± 1.41

7.56 ± 2.46*

7.20 ± 2.13*

7.70 ± 2.12*

8.93 ± 4.01*

Hb [g/dL]

14.2 ± 1.3

14.2 ± 2.4

14.6 ± 2.5

13.9 ± 2.3

13.5 ± 1.9

LDH [U/L]

199.9 ± 66.0

285.6 ± 91.0*

277.6 ± 62.0*

279.5 ± 70.9*

324.2 ± 173.2*

Bilirubin [mg/dL]

0.55 ± 0.20

0.80 ± 0.50

0.78 ± 0.47

0.78 ± 0.39

0.88 ± 0.75

  1. TSP-1 thrombospondin 1, bigET big Endothelin, PDGF-ββ platelet derived growth factor ββ, PF4 platelet factor 4, SDF-1α stroma derived factor 1α, NT-proBNP N-terminal pro-brain natriuretic peptide
  2. Data is expressed as mean ± SD, *p < 0.05 vs. Control, **p < 0.05 vs. PAH, ***p < 0.05 vs. LD, marks in brackets signify statistical trends (0.05 < p < 0.01)