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Table 2 Summary of common and discordant enrichment of pathways between BAL cell, lung tissue and PBLs in subjects with sarcoidosis

From: Sarcoidosis activates diverse transcriptional programs in bronchoalveolar lavage cells

Selective list of pathways upregulated in both BAL cell and lung tissue biopsies of sarcoidosis patients
Graft vs. host disease
T cell receptor signaling
Allograft rejection
Primary immunodeficiency
Natural killer cell mediated cytotoxicity
Csk pathway (activation of Csk by cAMP-dependent protein kinase inhibits signaling through T cell receptor)
Immunoregulatory interaction between lymphoid and non lymphoid cell
IL12 pathway
TCRA pathway (Lck and Fyn tyrosine kinases in initiation of T cell receptor activation)
Th1 Th2 pathway
CTL pathway (cytotoxic T lymphocyte mediated immune response against target cells)
NKT (natural killer T cell) pathway
Autoimmune thyroid disease
CTLA4 (cytotoxic T-lymphocyte-associated protein 4) pathway
PD-1 (programmed death-1) signaling
Type 1 diabetes mellitus
Pathways upregulated in both BAL cell and PBLs of sarcoidosis patients
 Antigen processing cross presentation
 RIP (receptor-interacting protein)-mediated NFkB activation via DAI (DNA-dependent activator of interferon)
Pathways upregulated in BAL cell and lung tissue but downregulated in PBLs of sarcoidosis patients
 T cell receptor pathway
 Csk pathway (activation of Csk by cAMP-dependent protein kinase inhibits signaling through T cell receptor)
 TCRA pathway (Lck and Fyn tyrosine kinases in initiation of T cell receptor activation)
 CTLA4 (cytotoxic T-lymphocyte-associated protein 4) pathway