Table 2 Summary of common and discordant enrichment of pathways between BAL cell, lung tissue and PBLs in subjects with sarcoidosis

Selective list of pathways upregulated in both BAL cell and lung tissue biopsies of sarcoidosis patients

Graft vs. host disease

T cell receptor signaling

Allograft rejection

Primary immunodeficiency

Natural killer cell mediated cytotoxicity

Csk pathway (activation of Csk by cAMP-dependent protein kinase inhibits signaling through T cell receptor)

Immunoregulatory interaction between lymphoid and non lymphoid cell

IL12 pathway

TCRA pathway (Lck and Fyn tyrosine kinases in initiation of T cell receptor activation)

Th1 Th2 pathway

CTL pathway (cytotoxic T lymphocyte mediated immune response against target cells)

NKT (natural killer T cell) pathway

Autoimmune thyroid disease

CTLA4 (cytotoxic T-lymphocyte-associated protein 4) pathway

PD-1 (programmed death-1) signaling

Type 1 diabetes mellitus

Pathways upregulated in both BAL cell and PBLs of sarcoidosis patients

 Antigen processing cross presentation

 RIP (receptor-interacting protein)-mediated NFkB activation via DAI (DNA-dependent activator of interferon)

Pathways upregulated in BAL cell and lung tissue but downregulated in PBLs of sarcoidosis patients

 T cell receptor pathway

 Csk pathway (activation of Csk by cAMP-dependent protein kinase inhibits signaling through T cell receptor)

 TCRA pathway (Lck and Fyn tyrosine kinases in initiation of T cell receptor activation)

 CTLA4 (cytotoxic T-lymphocyte-associated protein 4) pathway