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Fig. 2 | Respiratory Research

Fig. 2

From: Pulmonary effects of inhalation of spark-generated silver nanoparticles in Brown-Norway and Sprague–Dawley rats

Fig. 2

Panels a & b: Silver quantification using ICP-MS in lung tissue following inhalation of the high dose of freshly-generated silver nanoparticles. In both rat strains, there was a reduction in lung silver content at Day 7 compared to Day 1, although this only reached statistical significance in the Sprague–Dawley rats. The silver lung content was higher in Brown-Norway rats compared to Sprague–Dawley rats. Panels c & d: Counts of macrophages staining positive for silver in the lung tissue of Sprague Dawley and Brown Norway rats exposed to silver nanoparticles at 1 and 7 days post inhalation at each lung dose deposition. Data for individual rats are shown with the median for each group denoted as a horizontal bar. *P < 0.05, **P < 0.01, ***P < 0.001 versus the air only control within each time-point

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