Differential effect of mild and severe pulmonary embolism on the rat lung transcriptome

Zagorski, John; Kline, Jeffrey A.

doi:10.1186/s12931-016-0405-9

Respiratory Research

Table 3 DAVID Functional Annotation Charts, 2-h Severe PE and 18-h Mild PE verses Vehicle

From: Differential effect of mild and severe pulmonary embolism on the rat lung transcriptome

		^a2-h Severe-PE verses Vehicle					18-h Mild-PE verses Vehicle
Category	Term	Ct	%	Dir	Fold	B&H	Ct	%	Dir	Fold	B&H
SP_PIR	acetylation						78	14.03	UP	1.51	0.009
SP_PIR	activator	7	7.29	UP	5.58	0.025
rno00970	Aminoacyl-tRNA biosynthesis						8	1.44	UP	5.56	0.017
rno00330	Arginine and proline metabolism						9	1.62	UP	4.72	0.015
rno05217	Basal cell carcinoma						10	1.11	D	4.28	0.016
IPR011700	Basic leucine zipper	4	4.17	UP	41.80	0.004
IPR004827	Basic-leucine zipper (bZIP) transcription factor	8	8.33	UP	28.54	0.000
SM00338	BRLZ	8	8.33	UP	20.66	0.000
IPR011616	bZIP transcription factor, bZIP-1	4	4.17	UP	25.44	0.015
rno04062	Chemokine signaling pathway						20	3.60	UP	3.25	0.001
*SP_PIR*	*chemotaxis*	4	*4.17*	UP	*20.78*	*0.025*	11	*1.98*	UP	*10.30*	*0.000*
rno04610	Complement and coagulation cascades						10	1.80	UP	3.97	0.019
*SP_PIR*	*cytokine*	9	*9.38*	UP	*15.21*	*0.000*	16	*2.88*	UP	*4.88*	*0.000*
rno04060	Cytokine-cytokine receptor interaction						23	4.14	UP	3.25	0.000
SP_PIR	disulfide bond						76	13.67	UP	1.43	0.044
SP_PIR	DNA binding	6	6.25	UP	7.38	0.028
SP_PIR	dna-binding	15	15.63	UP	3.75	0.002
UP_SEQ	DNA-binding region: Basic motif	10	10.42	UP	15.44	0.000
UP_SEQ	domain: Leucine-zipper	9	9.38	UP	19.96	0.000
rno00982	Drug metabolism						13	1.45	D	3.94	0.004
rno04512	ECM-receptor interaction						14	1.56	D	3.77	0.005
PIRSF001719	fos transforming protein	4	4.17	UP	109.20	0.000
IPR000837	Fos transforming protein	4	4.17	UP	83.59	0.001
rno00480	Glutathione metabolism						9	1.00	D	3.93	0.042
rno00340	Histidine metabolism						7	0.78	D	6.37	0.017
*SP_PIR*	*inflammatory response*	4	*4.17*	UP	*16.51*	*0.027*	11	*1.98*	UP	*8.18*	*0.000*
rno00980	Metabolism of xenobiotics by cytochrome P450						13	1.45	D	4.73	0.002
*rno04621*	*NOD-like receptor signaling pathway*	5	*5.21*	UP	*12.52*	*0.034*	10	*1.80*	UP	*4.49*	*0.016*
SP_PIR	nucleus	22	22.92	UP	2.01	0.026
SP_PIR	oxidoreductase						42	4.68	D	1.89	0.034
rno05020	Prion diseases						7	1.26	UP	5.56	0.028
SP_PIR	ribosome biogenesis						7	1.26	UP	8.85	0.007
*SM00199*	*SCY*	5	*5.21*	UP	*18.26*	*0.003*	10	*1.80*	UP	*8.76*	*0.000*
*IPR001811*	*Small chemokine, interleukin-8-like*	5	*5.21*	UP	*25.22*	*0.002*	10	*1.80*	UP	*8.70*	*0.001*
SP_PIR	Transcription	14	14.58	UP	3.23	0.009
SP_PIR	transcription regulation	14	14.58	UP	3.48	0.006

Functional annotations significantly over-represented in the lists of up-regulated and down-regulated genes during 2-h Severe PE and 18-h Mild PE. Annotations unique to both treatments are highlighted in bold Italics; unique annotations are in standard font. Keys are the same as in Table 1. ^aNo 2-h DOWN Annotations meet B&H < 0.05

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