Fig. 6

Quantification of total basal cells and KRT5⁺ and KRT14⁺ basal cell subpopulations in the IPF lung. a, b Cells were counted according to their positivity for p63, KRT5 or KRT14 immunostaining in (a) conducting airways (1 donor, 2 samples, n = 7 assessed fields/sample) and (b) in distal regions (5 donors, 1-3 samples/donor, n = 34 assessed fields in bronchiolized regions (striped bars), n = 24 assessed fields in fibrotic regions (black bars), n = 11 assessed fields in non fibrotic regions (white bars)). Data are expressed as mean ± SEM. a A 1-Way ANOVA revealed a significant interaction (p < 0.0001). The data were further analyzed for significance with a Dunn’s post-test (**p < versus “KRT5⁺”). b A 2-Way ANOVA with Bonferroni post-test revealed a significant interaction according to the type of remodeled region (p < 0.0001). Each dataset (bronchiolization, fibrotic, non fibrotic) was then compared separately with a 1-Way ANOVA test, with a Dunn’s post-test: ***p < 0.001 versus the neighboring “Bronchiolization” column, ^### p < 0.001 between “Bronchiolization KRT5⁺” and “Bronchiolization KRT14⁺”