Skip to main content

Table 4 Cox analysis for prognostic factors for overall survival from the idiopathic pulmonary fibrosis initial diagnosis

From: Risk factors for an acute exacerbation of idiopathic pulmonary fibrosis

  HR (95 % CI) P Value
Treatment after diagnosis
Immunosuppressive agent
 Unadjusted 2.40 (0.96 to 6.02) 0.062
Cardiovascular diseases
 Unadjusted 2.08 (0.91 to 4.54) 0.086
 Adjusteda 2.37 (1.03 to 5.44) 0.042
GAP stage (≥II)
 Unadjusted 4.02 (1.68 to 9.64) 0.002
 Adjusteda 3.63 (1.47 to 8.93) 0.005
Serum markers
LDH, U/L, Cut off point = 180
 Unadjusted 2.49 (0.74 to 8.37) 0.139
 Adjusteda 2.24 (0.66 to 7.63) 0.198
KL-6, U/mL, Cut off point = 946
 Unadjusted 1.46 (0.67 to 3.18) 0.340
 Adjusteda 1.45 (0.67 to 3.17) 0.345
SP-D, ng/mL, Cut off point = 194.7
 Unadjusted 3.49 (1.36 to 8.94) 0.009
 Adjusteda 3.21 (1.21 to 8.48) 0.019
BAL fluid findings
Lymphocytes, %, Cut off point = 10.15
 Unadjusted 1.96 (0.93 to 4.14) 0.077
 Adjusteda 1.99 (0.94 to 4.21) 0.072
Neutrophils, %, Cut off point = 1.77
 Unadjusted 2.48 (0.73 to 8.45) 0.147
 Adjusteda 2.21 (0.63 to 7.69) 0.213
Eosinophils, %, Cut off point = 3.21
 Unadjusted 2.42 (1.03 to 5.68) 0.043
 Adjusteda 2.20 (0.92 to 5.25) 0.075
  1. Abbreviations: HR hazard ratio, CI confidence interval, GAP gender-age-physiology, LDH lactate dehydrogenase, KL-6 Krebs von den Lungen-6, SP-D surfactant protein-D, BAL bronchoalveolar lavage
  2. aAdjusted for immunosuppressive agent therapy
\