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Table 4 Cox analysis for prognostic factors for overall survival from the idiopathic pulmonary fibrosis initial diagnosis

From: Risk factors for an acute exacerbation of idiopathic pulmonary fibrosis

 

HR

(95 % CI)

P Value

Treatment after diagnosis

Immunosuppressive agent

 Unadjusted

2.40

(0.96 to 6.02)

0.062

Cardiovascular diseases

 Unadjusted

2.08

(0.91 to 4.54)

0.086

 Adjusteda

2.37

(1.03 to 5.44)

0.042

GAP stage (≥II)

 Unadjusted

4.02

(1.68 to 9.64)

0.002

 Adjusteda

3.63

(1.47 to 8.93)

0.005

Serum markers

LDH, U/L, Cut off point = 180

 Unadjusted

2.49

(0.74 to 8.37)

0.139

 Adjusteda

2.24

(0.66 to 7.63)

0.198

KL-6, U/mL, Cut off point = 946

 Unadjusted

1.46

(0.67 to 3.18)

0.340

 Adjusteda

1.45

(0.67 to 3.17)

0.345

SP-D, ng/mL, Cut off point = 194.7

 Unadjusted

3.49

(1.36 to 8.94)

0.009

 Adjusteda

3.21

(1.21 to 8.48)

0.019

BAL fluid findings

Lymphocytes, %, Cut off point = 10.15

 Unadjusted

1.96

(0.93 to 4.14)

0.077

 Adjusteda

1.99

(0.94 to 4.21)

0.072

Neutrophils, %, Cut off point = 1.77

 Unadjusted

2.48

(0.73 to 8.45)

0.147

 Adjusteda

2.21

(0.63 to 7.69)

0.213

Eosinophils, %, Cut off point = 3.21

 Unadjusted

2.42

(1.03 to 5.68)

0.043

 Adjusteda

2.20

(0.92 to 5.25)

0.075

  1. Abbreviations: HR hazard ratio, CI confidence interval, GAP gender-age-physiology, LDH lactate dehydrogenase, KL-6 Krebs von den Lungen-6, SP-D surfactant protein-D, BAL bronchoalveolar lavage
  2. aAdjusted for immunosuppressive agent therapy