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Table 2 Log-rank test for risk factors for an acute exacerbation of idiopathic pulmonary fibrosis

From: Risk factors for an acute exacerbation of idiopathic pulmonary fibrosis

  Non-AE (N = 41) AE (N = 24) log-rank P Value
Smoking
 S or Ex 32 20 0.918
 N 9 4  
Cardiovascular diseases
 Yes 10 8 0.042
 No 31 16  
GAP stage
 II or III 11 12 0.002
 I 25 10  
Serum markers
LDH
  ≥ 180 32 22 0.048
  < 180 9 2  
KL-6    
  ≥ 946 18 16 0.292
  < 946 21 8  
SP-D
  ≥ 194.7 22 18 0.014
  < 194.7 17 6  
BAL fluid findings
Lymphocytes
  ≥ 10.15 13 13 0.085
  < 10.15 28 11  
Neutrophils
  ≥ 1.77 34 22 0.048
  < 1.77 7 2  
Eosinophils
  ≥ 3.21 21 17 0.009
  < 3.21 20 7  
Treatment after the diagnosis
Steroid
 Yes 7 8 0.443
 No 34 16  
Immunosuppressive agent
 Yes 3 6 0.009
 No 38 18  
Pirfenidone
 Yes 8 6 0.963
 No 33 18  
NAC
 Yes 8 5 0.547
 No 33 19  
  1. Abbreviations: AE acute exacerbation, N number of patients, S/Ex/N current smoker/ex-smoker/nonsmoker, GAP gender-age-physiology, LDH lactate dehydrogenase, KL-6 Krebs von den Lungen-6, SP-D surfactant protein-D, BAL bronchoalveolar lavage, NAC inhaled N-acetylcysteine
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