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Table 2 Log-rank test for risk factors for an acute exacerbation of idiopathic pulmonary fibrosis

From: Risk factors for an acute exacerbation of idiopathic pulmonary fibrosis

 

Non-AE (N = 41)

AE (N = 24)

log-rank P Value

Smoking

 S or Ex

32

20

0.918

 N

9

4

 

Cardiovascular diseases

 Yes

10

8

0.042

 No

31

16

 

GAP stage

 II or III

11

12

0.002

 I

25

10

 

Serum markers

LDH

  ≥ 180

32

22

0.048

  < 180

9

2

 

KL-6

   

  ≥ 946

18

16

0.292

  < 946

21

8

 

SP-D

  ≥ 194.7

22

18

0.014

  < 194.7

17

6

 

BAL fluid findings

Lymphocytes

  ≥ 10.15

13

13

0.085

  < 10.15

28

11

 

Neutrophils

  ≥ 1.77

34

22

0.048

  < 1.77

7

2

 

Eosinophils

  ≥ 3.21

21

17

0.009

  < 3.21

20

7

 

Treatment after the diagnosis

Steroid

 Yes

7

8

0.443

 No

34

16

 

Immunosuppressive agent

 Yes

3

6

0.009

 No

38

18

 

Pirfenidone

 Yes

8

6

0.963

 No

33

18

 

NAC

 Yes

8

5

0.547

 No

33

19

 
  1. Abbreviations: AE acute exacerbation, N number of patients, S/Ex/N current smoker/ex-smoker/nonsmoker, GAP gender-age-physiology, LDH lactate dehydrogenase, KL-6 Krebs von den Lungen-6, SP-D surfactant protein-D, BAL bronchoalveolar lavage, NAC inhaled N-acetylcysteine