Risk factors for an acute exacerbation of idiopathic pulmonary fibrosis

Respiratory Research

Table 2 Log-rank test for risk factors for an acute exacerbation of idiopathic pulmonary fibrosis

	Non-AE (N = 41)	AE (N = 24)	log-rank P Value
Smoking
S or Ex	32	20	0.918
N	9	4
Cardiovascular diseases
Yes	10	8	0.042
No	31	16
GAP stage
II or III	11	12	0.002
I	25	10
Serum markers
LDH
≥ 180	32	22	0.048
< 180	9	2
KL-6
≥ 946	18	16	0.292
< 946	21	8
SP-D
≥ 194.7	22	18	0.014
< 194.7	17	6
BAL fluid findings
Lymphocytes
≥ 10.15	13	13	0.085
< 10.15	28	11
Neutrophils
≥ 1.77	34	22	0.048
< 1.77	7	2
Eosinophils
≥ 3.21	21	17	0.009
< 3.21	20	7
Treatment after the diagnosis
Steroid
Yes	7	8	0.443
No	34	16
Immunosuppressive agent
Yes	3	6	0.009
No	38	18
Pirfenidone
Yes	8	6	0.963
No	33	18
NAC
Yes	8	5	0.547
No	33	19

Abbreviations: AE acute exacerbation, N number of patients, S/Ex/N current smoker/ex-smoker/nonsmoker, GAP gender-age-physiology, LDH lactate dehydrogenase, KL-6 Krebs von den Lungen-6, SP-D surfactant protein-D, BAL bronchoalveolar lavage, NAC inhaled N-acetylcysteine

ISSN: 1465-993X