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Table 3 Complications during the study

From: A phase II trial evaluating the efficacy and safety of perioperative pirfenidone for prevention of acute exacerbation of idiopathic pulmonary fibrosis in lung cancer patients undergoing pulmonary resection: West Japan Oncology Group 6711 L (PEOPLE Study)

 

Preoperative complications (n = 43)

Postoperative complications (n = 37)

Grade 1, 2

Grade 3–5

Grade 1, 2

Grade 3–5

Photosensitivity

1

0

0.0 %

0

0

0.0 %

Anorexia

4

0

0.0 %

5

1

(Grade 4, 2.7 %)

Nausea

4

0

0.0 %

3

0

0.0 %

Diarrhea

0

0

0.0 %

1

0

0.0 %

Somnolence

1

0

0.0 %

0

0

0.0 %

Dizziness

2

0

0.0 %

1

0

0.0 %

Malaise

2

0

0.0 %

2

0

0.0 %

Respiratory failure

0

0

0.0 %

0

1

(Grade 4, 2.7 %)

Dyspnea

0

0

0.0 %

5

1

(Grade 4, 2.7 %)

Pulmonary fistula

0

0

0.0 %

2

0

0.0 %

Postoperative hemorrhage

0

0

0.0 %

1

0

0.0 %

Cough

0

0

0.0 %

1

0

0.0 %

Atrial fibrillation

0

0

0.0 %

1

0

0.0 %

Wound dehiscence

0

0

0.0 %

1

0

0.0 %

Pneumonitis

0

0

0.0 %

0

1

(Grade 5, 2.7 %)

Dysgeusia

0

0

0.0 %

1

0

0.0 %

White blood cell decreased

0

0

0.0 %

2

0

0.0 %

Neutrophil count decreased

0

0

0.0 %

1

0

0.0 %

Anemia

2

0

0.0 %

4

0

0.0 %

Hypoalbuminemia

2

0

0.0 %

19

0

0.0 %

ALP increased

2

0

0.0 %

8

0

0.0 %

Blood bilirubin increased

0

0

0.0 %

1

0

0.0 %

AST increased

3

0

0.0 %

8

1

(Grade 3, 2.7 %)

ALT increased

3

0

0.0 %

6

0

0.0 %

GGT increased

5

0

0.0 %

6

0

0.0 %

Creatinine increased

1

0

0.0 %

0

0

0.0 %

Hyponatremia

3

0

0.0 %

8

1

(Grade 3, 2.7 %)

Hyperkalemia

1

0

0.0 %

0

0

0.0 %

Hypokalemia

0

0

0.0 %

3

0

0.0 %

Hypocalcemia

0

0

0.0 %

3

0

0.0 %

  1. ALP alkaline phosphatase, AST aspartate aminotransferase, ALT alanine aminotransferase, GGT γ-glutamyltransferase