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Table 4 Sensitivity analysis results from multivariable analyses evaluating the relationship between independent variables and 30-day hospital and ICU mortality

From: Risk factors for mortality in patients admitted to intensive care units with pneumonia

Independent variables Hospital mortalitya ICU mortalityb
HR (95 % CI) P-value HR (95 % CI) P-value
Baseline variables
Male 1.39 (0.96-1.96) 0.090 1.30 (0.85-2.04) 0.22
APACHE II scorec 1.29 (1.14-1.47) <0.001 1.20 (1.06-1.37) 0.004
History of malignancy 1.46 (0.70-3.03) 0.31 -d -d
End-stage renal disease 1.13 (0.38-3.39) 0.82 -d -d
Chronic respiratory disease 1.49 (0.98-2.27) 0.063 1.45 (0.92-2.28) 0.11
Chronic heart failure 2.25 (1.16-4.34) 0.017 2.57 (1.32-5.02) 0.006
History of venous thromboembolism 0.76 (0.28-2.09) 0.59 0.52 (0.13-2.12) 0.36
Immunocompromise 1.48 (0.91-2.41) 0.12 1.43 (0.85-2.39) 0.17
Daily intervention variables
Inotropes/vasopressors 1.21 (0.84-1.75) 0.31 1.07 (0.71-1.62) 0.75
Dialysis 2.29 (1.03-5.11) 0.042 1.33 (0.59-2.98) 0.49
Red blood cell transfusion 1.20 (0.62-2.30) 0.59 1.38 (0.67-2.84) 0.39
Central venous catheterization 1.50 (0.86-2.63) 0.15 1.12 (0.62-2.01) 0.72
Acetylsalicylic acid or clopidogrel 1.36 (0.93-2.00) 0.11 -d -d
Erythropoietin-stimulating agents -e -e 1.39 c0.32-6.04) 0.66
  1. HR hazard ratio, CI confidence interval, BMI body mass index, APACHE Acute Physiology and Chronic Health Evaluation
  2. aThere were 122 deaths for 30-day hospital mortality; No multicollinearity detected
  3. bThere were 97 deaths for 30-day hospital mortality; No multicollinearity detected
  4. cResults for 5-point increase
  5. dNot included in the multivariable analysis for ICU mortality
  6. eNot included in the multivariable analysis for hospital mortality