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Table 3 Results from univariate and multivariable analyses investigating the relationship between independent variables and 90-day ICU mortality

From: Risk factors for mortality in patients admitted to intensive care units with pneumonia

Independent variables ICU mortalitya
Univariate analysis Multivariable analysisb
HR (95 % CI) P-value HR (95 % CI) P-value
Baseline variables
 Male 1.52 (1.01-2.22) 0.042 1.41 (0.95-2.08) 0.096
 APACHE II scorec 1.20 (1.07-1.35) 0.002 1.22 (1.07-1.37) 0.002
 Chronic respiratory disease 1.47 (0.97-2.23) 0.071 1.27 (0.81-1.97) 0.30
 Chronic heart failure 2.48 (1.33-4.64) 0.004 2.58 (1.34-4.97) 0.004
 History of venous thromboembolism 0.28 (0.068-1.16) 0.078 0.46 (0.11-1.91) 0.29
 Immunocompromise 1.45 (0.91-2.33) 0.11 1.54 (0.94-2.52) 0.084
 BMIc 0.97 (0.85-1.10) 0.61 -d -d
 History of malignancy 1.29 (0.57-2.94) 0.54 -d -d
 Medical admission 1.24 (0.31-5.04) 0.76 -d -d
 End-stage renal disease 1.49 (0.50-4.40) 0.47 -d -d
 Chronic hepatic failure 1.21 (0.17-8.67) 0.85 -d -d
Daily intervention variables
 Inotropes/vasopressors 1.35 (0.92-1.98) 0.12 1.29 (0.88-1.92) 0.19
 Dialysis 2.06 (1.04-4.09) 0.039 1.64 (0.77-3.52) 0.20
 Red blood cell transfusion 1.60 (0.83-3.09) 0.16 1.30 (0.63-2.70) 0.48
 Central venous catheterization 1.75 (0.93-3.27) 0.081 1.63 (0.92-2.87) 0.090
 Erythropoietin-stimulating agents 2.66 (0.65-10.85) 0.17 1.15 (0.23-5.79) 0.86
 Mechanical ventilation 1.05 (0.46-2.40) 0.91 -d -d
 Acetylsalicylic acid or clopidogrel 1.22 (0.82-1.81) 0.32 -d -d
 Statins 0.93 (0.56-1.55) 0.78 -d -d
 Stress ulcer prophylaxis 1.33 (0.64-2.74) 0.44 -d -d
 Activated protein C 0.86 (0.21-3.50) 0.84 -d -d
  1. HR hazard ratio, CI confidence interval, BMI body mass index, APACHE Acute Physiology and Chronic Health Evaluation
  2. aThere were 108 deaths for 90-day ICU mortality
  3. bNo multicollinearity detected
  4. cResults for 5-point increase
  5. dNot included in the multivariable analysis