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Table 2 Results from univariate and multivariable analyses assessing the relationship between independent variables and 90-day hospital mortality

From: Risk factors for mortality in patients admitted to intensive care units with pneumonia

Independent variables Hospital mortalitya
Univariate analysis Multivariable analysisb
HR (95 % CI) P-value HR (95 % CI) P-value
Baseline variables
 Male 1.37 (0.97-1.92) 0.074 1.52 (1.07-2.17) 0.021
 APACHE II scorec 1.25 (1.13-1.38) <0.001 1.23 (1.10-1.37) <0.001
 History of malignancy 1.84 (0.99-3.41) 0.053 1.61 (0.82-3.15) 0.16
 End-stage renal disease 1.96 (0.79-4.88) 0.15 1.12 (0.38-3.25) 0.84
 Chronic respiratory disease 1.40 (0.97-2.03) 0.073 1.36 (0.91-2.02) 0.14
 Chronic heart failure 2.71 (1.53-4.79) 0.001 2.90 (1.57-5.37) 0.001
 History of venous thromboembolism 0.50 (0.19-1.37) 0.18 0.64 (0.23-1.75) 0.38
 Immunocompromise 1.40 (0.93-2.12) 0.12 1.33 (0.84-2.12) 0.23
 BMIc 0.99 (0.89-1.10) 0.82 -d -d
 Medical admission 2.45 (0.61-9.90) 0.22 -d -d
 Chronic hepatic failure 0.65 (0.091-4.64) 0.67 -d -d
Daily intervention variables
 Inotropes/vasopressors 1.59 (1.15-2.19) 0.005 1.24 (0.88-1.75 0.22
 Dialysis 2.84 (1.52-5.30) 0.001 2.71 (1.30-5.65) 0.008
 Red blood cell transfusion 1.64 (0.93-2.91) 0.090 1.22 (0.67-2.21) 0.51
 Central venous catheterization 1.75 (1.04-2.94) 0.037 1.67 (0.99-2.80) 0.056
 Acetylsalicylic acid or clopidogrel 1.44 (1.03-2.01) 0.034 1.28 (0.90-1.81) 0.17
 Mechanical ventilation 1.34 (0.68-2.63) 0.40 -d -d
 Statins 1.27 (0.84-1.92) 0.26 -d -d
 Stress ulcer prophylaxis 1.43 (0.79-2.59) 0.23 -d -d
 Erythropoietin-stimulating agents 2.29 (0.57-9.30) 0.25 -d -d
 Activated protein C 1.64 (0.41-6.67) 0.49 -d -d
  1. HR hazard ratio, CI confidence interval, BMI body mass index, APACHE Acute Physiology and Chronic Health Evaluation
  2. aThere were 143 deaths for 90-day hospital mortality, bNo multicollinearity detected, cResults for 5-point increase, dNot included in the multivariable analysis