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Fig. 2 | Respiratory Research

Fig. 2

From: Tissue turnover of collagen type I, III and elastin is elevated in the PCLS model of IPF and can be restored back to vehicle levels using a phosphodiesterase inhibitor

Fig. 2

Levels of N-terminal propeptide of collagen type I (a), MMP-2, 9 and 13 generated fragments of collagen type I (b), N-terminal propeptide of collagen type III (c), MMP-9 generated fragments of collagen type III (d) and MMP-7 generated fragments of elastin (e) in the supernatant of the PCLS model after 48 h of culturing from animals euthanized fourteen days after last BLM or vehicle dosing. w/o: Williams E medium without any intervention; IBMX: Williams E medium + 100 μM IBMX; GM6001: Williams E medium + 10 μM GM6001. Black bars; slices from vehicle rats. Grey bars; slices from BLM-treated rats. Significance level: *p < 0.05, **p < 0.01, ****p < 0.0001

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Respiratory Research

ISSN: 1465-993X

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