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Table 4 Adjusted mean FEV1 and FVC outcomes at 6 weeks (full analysis set)

From: Evaluation of the effects of olodaterol on exercise endurance in patients with chronic obstructive pulmonary disease: results from two 6-week crossover studies

  

FEV1

FVC

Treatment

Planned time (min)

Mean (SE), L

Mean (SE) difference from placebo

p value

Mean (SE), L

Mean (SE) difference from placebo

p value

Study 1222.37

       

 Placebo

−0.30 (pre-dose/trough)

1.475 (0.017)a

  

3.212 (0.037)b

  

 Olodaterol 5 μg

 

1.564 (0.017)c

0.089 (0.017)

<0.0001

3.319 (0.037)a

0.107 (0.031)

0.0006

 Olodaterol 10 μg

 

1.576 (0.017)c

0.101 (0.017)

<0.0001

3.310 (0.037)a

0.098 (0.031)

0.0017

 Placebo

60 (post-dose)

1.473 (0.019)a

  

3.187 (0.034)b

  

 Olodaterol 5 μg

 

1.698 (0.019)c

0.224 (0.017)

<0.0001

3.471 (0.034)a

0.285 (0.029)

<0.0001

 Olodaterol 10 μg

 

1.699 (0.019)c

0.226 (0.017)

<0.0001

3.477 (0.034)a

0.290 (0.029)

<0.0001

Study 1222.38

       

 Placebo

−0.30 (pre-dose/trough)

1.520 (0.024)d

  

3.103 (0.039)d

  

 Olodaterol 5 μg

 

1.630 (0.025)e

0.110 (0.019)

<0.0001

3.222 (0.040)e

0.119 (0.036)

0.0013

 Olodaterol 10 μg

 

1.630 (0.025)f

0.110 (0.019)

<0.0001

3.222 (0.040)f

0.119 (0.037)

0.0013

 Placebo

60 (post-dose)

1.577 (0.026)d

  

3.144 (0.039)d

  

 Olodaterol 5 μg

 

1.768 (0.026)e

0.192 (0.021)

<0.0001

3.409 (0.040)e

0.265 (0.035)

<0.0001

 Olodaterol 10 μg

 

1.771 (0.026)f

0.195 (0.021)

<0.0001

3.425 (0.040)f

0.281 (0.035)

<0.0001

  1. a n = 136; b n = 135; c n = 137; d n = 146; e n = 143; f n = 139
  2. Common baseline means (SE): Study 1222.37, FEV1, 1.478 (0.043); FVC, 3.221 (0.073). Study 1222.38, FEV1, 1.553 (0.043); FVC, 3.160 (0.072)
  3. SE standard error, FEV 1 forced expiratory volume in 1 s, FVC forced vital capacity