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Fig. 3 | Respiratory Research

Fig. 3

From: Acute lung injury induced by whole gastric fluid: hepatic acute phase response contributes to increase lung antiprotease protection

Fig. 3

Pro-inflammatory cytokines and IL-10 levels in BALF, lung tissue homogenate and blood after instillation. a In the lung, IL-6 levels increased mainly in BALF, with a peak at 4 h and a progressive reduction to become non detectable at 4d. b IL-1β levels increased mainly in lung tissue homogenate with a peak level at 12 h and a significant reduction thereafter. c Levels of TNF-α showed a brief and moderate increment at 4 h both in BALF and lung tissue homogenate, with a significant reduction thereafter. d IL-10 levels in BALF showed a progressive increase between 4 h and 24 h and became non detectable at 4d, without changes in lung tissue homogenate. e In spite of the high levels of pro-inflammatory cytokines observed in the lung, only IL-6 was detected in plasma at 4 h after instillation. Open bars correspond to cytokine levels in BALF, solid bars correspond to cytokine levels in lung tissue homogenate and the hatched bar corresponds to IL-6 levels in plasma. Results are means ± SEM. *: p < 0.05; **: p < 0.01; ***: p < 0.001 with respect to control values. C: controls; h: hours; d: days; N.D.: non detectable

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