Fig. 8From: Ajulemic acid exerts potent anti-fibrotic effect during the fibrogenic phase of bleomycin lungAjA treatment in the fibrogenic phase increases the number PPAR-γ positive cells as well as the nuclear localization of the receptor. a Representative immunohistochemical staining of PPAR-γ in lung sections from the different experimental groups at 14 day after BLM challenge. PPAR-γ positive cells were significantly decreased after BLM challenge. Additionally, the nuclear stain for this receptor was very low in lung sections of control and BLM treated mice. AjA treatments at different doses significantly increase the number of PPAR-γ positive cells and its nuclear stain in lung slides. Scale bars = 60 μm. b The immunohistochemical score of cytoplasmic and nuclear staining for PPAR-γ in lung tissue from the various experimental groups is shownBack to article page