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Fig. 7 | Respiratory Research

Fig. 7

From: Ajulemic acid exerts potent anti-fibrotic effect during the fibrogenic phase of bleomycin lung

Fig. 7

AjA treatment in the fibrogenic phase reduces TGF-β1, pSMAD2/3 and CTGF expression. a Immunohistochemical staining of TGF-β1 at day 14 after BLM delivery in lung sections from control mouse, BLM-treated mouse with consolidated area of fibrosis, and mice receiving at day 8 from BLM delivery AjA at a dose of 1 mg/Kg and 5 mg/Kg. Scale bars = 60 μm. b Imunohistochemical staining of pSMAD2/3 in lung sections from the different experimental groups at day 14. Scale bars = 60 μm. c Representative immunohistochemical staining of CTGF in lung sections from the different experimental groups. Scale bars = 60 μm. d ELISA analysis of TGF-β1. BLM increased tissue levels of TGF-β1. e-f immunohistochemical score for pSMAD2/3 and CTGF in the different experimental groups. * p < 0.05 vs control; † p < 0.05 vs BLM

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