Fig. 6
From: Ajulemic acid exerts potent anti-fibrotic effect during the fibrogenic phase of bleomycin lung
Treatment of AjA in the fibrogenic phase of BLM-lung effectively limits the development of fibrosis as revealed by lung morphology and morphometry as well as HO-proline content. a Lung slides from mice at day 21 from control mouse, BLM-treated mouse, and mice receiving AjA at a dose of 1 mg/Kg and 5 mg/Kg at day 8 after BLM delivery. Masson’s trichrome staining, scale bars = 60 μm. b Histologic score in the different mouse groups. Data are reported as mean ± SD. *p < 0.05 vs control group. † p < 0.05 vs BLM group. c Lung HO-proline expressed as μg/lung in the various experimental groups. Data are reported as mean ± SD. *p < 0.05 vs control group. † p < 0.05 vs BLM group