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Fig. 3 | Respiratory Research

Fig. 3

From: Airway epithelial cell exposure to distinct e-cigarette liquid flavorings reveals toxicity thresholds and activation of CFTR by the chocolate flavoring 2,5-dimethypyrazine

Fig. 3

2,5-Dimethylpyrazine increases airway epithelial ion conductance. Primary MTE cells were voltage clamped in Ussing chambers and monitored for changes in Isc and TER following varying doses of 2,5-dimethylpyrazine. a Representative traces of Isc in response to 2,5-dimethylpyrazine demonstrate a concentration dependent increase in Isc. b A concentration-dependent curve of the change in Isc following 2,5-dimethylpyrazine. c Representative traces of TER in response to varying concentrations of 2,5-dimethylpyrazine demonstrate a concentration dependent drop in TER. Addition of 2,5-dimethylpyrazine on the apical airway epithelial surface results in an increase in apical ion efflux with a concurrent drop in TER

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