Fig. 8

Effects of Cav-1 upregulation on the structure and function of rat alveolar epithelial monolayers exposed to hyperoxic conditions. At 60–70 % confluence, alveolar epithelial cells were treated with empty vector and Cav-1 cDNA (1 μg/mL) transfection and then immediately exposed to hyperoxic conditions for 48 h. Tight junction structures (a, b, c, d, 20,000× or 80,000× magnification) were determined by TEM. Black arrows indicate the tight junction structures (b, d). TEER value (e) and Papp of FD4 (f) were also measured. Values are presented as means ± SD, ^# P < 0.05 for comparison with the hyperoxia-treated group, ^* P < 0.05 for comparison with the empty vector-transfected group