Advanced glycation endproducts and their receptor in different body compartments in COPD

Respiratory Research

Table 4 Associations between AGEs and RAGE expression in different tissues

		Plasma								Sputum								Bronchial biopsies				Skin
		CEL		CML		Pentosidine		sRAGE		CEL		CML		Pentosidine		sRAGE		AGE positivity		RAGE positivity		SAF
Predictor variables:		B	p	B	p	B	p	B	p	B	p	B	p	B	p	B	p	B	p	B	p	B	p
Plasma	CEL	---	---	0.42	0.34	-0.39	0.27	3.21	0.47	0.07	0.46	0.99	0.20	0.02	0.59	-3.70	0.21	0.43	0.08	0.28	0.04	0.00	0.91
	CML	0.01	0.34	---	---	0.11	0.07	-1.01	0.13	0.02	0.22	-0.13	0.34	0.00	0.77	0.51	0.28	0.07	0.03	0.00	0.78	0.00	0.72
	Pentosidine	-0.02	0.27	0.13	0.07	---	---	-1.84	0.01	0.04	0.01	-0.13	0.38	0.01	0.44	0.46	0.37	0.04	0.20	-0.01	0.51	0.00	0.81
	sRAGE	0.00	0.47	-0.01	0.13	-0.01	0.01	---	---	0.00	0.21	-0.01	0.57	0.00	0.46	0.04	0.30	-0.01	0.09	0.00	0.64	0.00	0.00*
Sputum	CEL	0.06	0.46	0.62	0.22	1.14	0.01	-6.92	0.21	---	---	2.93	0.00*	0.17	0.00*	-3.30	0.23	0.51	0.01	-0.07	0.53	0.00	0.91
	CML	0.01	0.20	-0.05	0.34	-0.04	0.38	-0.33	0.57	0.03	0.00*	---	---	0.00	0.50	-0.63	0.03	0.03	0.07	0.00	0.72	0.00	0.51
	Pentosidine	0.10	0.59	-0.25	0.77	0.58	0.44	6.77	0.46	0.47	0.00*	0.92	0.50	---	---	-5.94	0.21	0.12	0.70	-0.19	0.27	-0.01	0.50
	sRAGE	0.00	0.21	0.02	0.28	0.01	0.37	0.18	0.30	0.00	0.23	-0.06	0.03	0.00	0.21	---	---	0.00	0.96	0.00	0.95	0.00	0.63
Bronchial	AGE positivity	0.06	0.08	0.59	0.03	0.33	0.20	-4.99	0.09	0.14	0.01	0.92	0.07	0.01	0.70	0.09	0.96	---	---	0.10	0.07	0.00	0.39
biopsies	RAGE positivity	0.13	0.04	-0.13	0.78	-0.29	0.51	-2.52	0.64	-0.06	0.53	0.32	0.72	-0.06	0.27	-0.19	0.95	0.30	0.07	---	---	0.00	0.85
Skin	SAF	-0.10	0.91	-1.50	0.72	0.91	0.81	-154.97	0.00*	0.18	0.91	9.76	0.51	-0.62	0.50	23.76	0.63	3.15	0.39	0.37	0.85	---	---

B = regression coefficient for predictor variables. All models are adjusted for age, gender, packyears, BMI, LDL cholesterol, and triglycerides. * significant p-value after Benjamini Hochberg correction for multiple testing
CEL N^ε-(carboxyethyl)lysine, CML N^ε-(carboxymethyl)lysine, sRAGE soluble receptor for advanced glycation endproducts, AGE advanced glycation end products, RAGE receptor for advanced glycation endproducts, SAF skin autofluorescence

ISSN: 1465-993X