Advanced glycation endproducts and their receptor in different body compartments in COPD

Respiratory Research

Table 3 Associations of AGEs and RAGEs with COPD and lung function in the total population

A. Associations of AGEs with COPD and lung function
Dependent variables		Predictor variables
		COPD, n/y		FEV1, % predicted		FEV1/FVC (%)		RV/TLC (%)		FEF25-75, % predicted
		β	p-value	β	p-value	β	p-value	β	p-value	β	p-value
Plasma	CEL	0.009	0.924	-0.465	0.642	0.581	0.562	0.117	0.204	0.0.41	0.635
	CML	0.093	0.327	-0.081	0.283	-0.088	0.337	0.052	0.572	-0.027	0.761
	Pentosidine	-0.035	0.711	-0.020	0.788	0.069	0.451	0.093	0.314	-0.011	0.901
Sputum	CEL	0.093	0.311	-0.139	0.101	-0.044	0.691	0.11	0.353	-0.059	0.518
	CML	0.029	0.757	-0.030	0.728	0.043	0.706	0.021	0.862	0.000	0.998
	Pentosidine	-0.025	0.792	-0.124	0.152	0.022	0.844	-0.024	0.841	-0.053	0.568
Bronchial biopsies	AGE positivity	-0.065	0.550	0.139	0.155	0.075	0.551	-0.126	0.420	0.094	0.379
Skin	SAF	0.426	<0.001	-0.302	<0.001	-0.357	<0.001	0.265	<0.001	-0.347	<0.001
B. Associations of RAGE with COPD and lung function
Dependent variables		Predictor variables
		COPD, n/y		FEV1, % predicted		FEV1/FVC (%)		RV/TLC (%)		FEF25-75, % predicted
		β	p-value	β	p-value	β	p-value	β	p-value	β	p-value
Plasma	sRAGE	-0.422	<0.001	0.310	<0.001	0.405	<0.001	-0.236	0.002	0.297	<0.001
Sputum	sRAGE	-0.110	0.194	0.084	0.289	0.012	0.908	-0.015	0.895	-0.041	0.622
Bronchial biopsies	RAGE positivity	-0.083	0.365	-0.053	0.529	0.04	0.715	0.241	0.060	-0.038	0.678

Values in bold represent significant associations. β = standardized regression coefficient for predictor variables. Models in Table A were adjusted for age, gender, packyears, BMI, LDL cholesterol and triglycerides; models in Table B were adjusted for age, gender and packyears
FEV ₁ forced expiratory volume in one second, FVC forced expiratory volume, RV residual volume, TLC total lung capacity, FEF forced expiratory flow, CEL N^ε-(carboxyethyl)lysine, CML N^ε-(carboxymethyl)lysine, AGEs advanced glycation endproducts, SAF skin autofluorescence, RAGE receptor for advanced glycation endproducts

ISSN: 1465-993X