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Table 5 Number of events needed to explore the effect of therapy in patients with COPD

From: Defining a COPD composite safety endpoint for demonstrating efficacy in clinical trials: results from the randomized, placebo-controlled UPLIFT® trial

  Events
Power (%) Year GOLD II GOLD III GOLD IV Overall
80 1 226 845 436 429
  2 331 1367 638 605
  3 375 1467 1244 695
  4 546 2538 1499 1033
85 1 259 967 499 491
  2 379 1564 730 692
  3 429 1678 1423 795
  4 625 2903 1714 1181
90 1 303 1131 584 575
  2 443 1830 854 810
  3 503 1964 1666 930
  4 731 3397 2006 1383
  1. The calculations were made with a power of 80 %, 85 %, and 90 % at p < 0.05
  2. GOLD Global Initiative for Chronic Obstructive Lung Disease