Tiotropium (n = 2986) | Control (n = 3006) | Tiotropium/control | ||||||
---|---|---|---|---|---|---|---|---|
Year | N (%) | Patient -year | IRa | N (%) | Patient-year | IRa | RR-year | p-value |
(95 % CI) | ||||||||
1 | 436 (15) | 2711.4 | 16.1 | 556 (19) | 2637.5 | 21.1 | 0.76 | <0.0001 |
(0.67–0.86) | ||||||||
2 | 664 (22) | 5146.1 | 12.9 | 803 (27) | 4959.0 | 16.2 | 0.80 | <0.0001 |
(0.72–0.88) | ||||||||
3 | 843 (28) | 7373.7 | 11.4 | 992 (33) | 7059.6 | 14.1 | 0.81 | <0.0001 |
(0.74–0.89) | ||||||||
4 | 995 (33) | 9442.9 | 10.5 | 1128 (38) | 9007.5 | 12.5 | 0.84 | 0.0001 |
(0.77–0.92) |