Table 2 Asthma disease characteristics by cohort at baseline visit

N (total/sputum)

52/32

55/38

51/40

Age (years)

33.7 (13.1)

45.0 (11.6)

46.2 (12.1)

<10⁻⁶

Pre-BD FEV1 (% predicted)

92.7 (14.3)

73.6 (10.4)

65.4 (12.7)

< 10⁻⁶

Pre-BD FEV1/FVC ratio

0.77 (0.08)

0.66 (0.09)

0.61 (0.09)

< 10⁻⁶

Post-BD FVC (% predicted)

105.0 (15.5)

96.4 (11.4)

94.0 (15.1)

0.0004

BDR (% change in FEV1)

8.5 (8.3)

15.2 (10.3)

18.3 (14.5)

0.0016

BDR (mL change in FEV1)

265.1 (231.7)

335.2 (234.3)

355.7 (270.6)

0.45

ACQ7

0.84 (0.69)

1.33 (0.71)

1.92 (1.01)

< 10⁻⁶

AQLQ

5.86 (0.93)

5.68 (1.11)

5.09 (1.28)

0.0016

FENO (ppb) **

32.9 (+64.2/−16.9)

29.1 (+61.0/−13.9)

28.8 (+64.7/−12.9)

0.59

Sputum eosinophils, % of WBC **

1.12 (+5.38/−0.93)

3.12 (+13.62/−2.54)

2.70 (+12.27/−2.21)

0.033

Sputum lymphocytes, % of WBC

1.29 (1.42)

0.98 (1.19)

0.94 (1.25)

0.48

Sputum macrophages, % of WBC

50.20 (31.17)

32.10 (21.45)

43.04 (26.46)

0.019

Sputum neutrophils, % of WBC

43.88 (30.90)

56.99 (26.13)

48.10 (25.52)

0.13