Fig. 7
From: CD4+ and CD8+ T cells play a central role in a HDM driven model of allergic asthma
Effect of budesonide on HDM induced airway inflammation and airway responsiveness to inhaled 5-HT. Male C57bl/6 mice were sensitised with HDM, and subsequently challenged with saline or HDM. Mice were treated with vehicle (0.5 % methylcellulose plus 0.2 % tween80 in water) or budesonide (3 mg/kg). Mice were placed in WBP chambers 3 days after final HDM challenge and airway responsiveness to inhaled 5-HT was assessed as Penh (e). Data (n = 12) expressed as mean Penh AUC ± S.E.M. Immediately after AHR assessment the lungs were lavaged and BALF eosinophil (a), neutrophil (b), lymphocyte (c) and total white cell (d) numbers were determined. Data (n = 12) expressed as mean cell number (103/ml) ± S.E.M. #p < 0.05 vs. relevant HDM-sensitised/saline-challenged controls, Mann-Whitney U-test. *p < 0.05 vs. relevant challenged/vehicle-treated controls, Mann-Whitney U-test