Fig. 11
From: CD4+ and CD8+ T cells play a central role in a HDM driven model of allergic asthma
The role of IgE in HDM induced airway inflammation and airway responsiveness to inhaled 5-HT. Male WT C57bl/6 and IgE KO mice were sensitised with HDM and subsequently challenged with saline or HDM. Mice were placed in WBP chambers 3 days after final HDM challenge and airway responsiveness to inhaled 5-HT was assessed as Penh (e). Data (n = 8) expressed as mean Penh AUC ± S.E.M. Immediately after AHR assessment the lungs were lavaged and BALF eosinophil (a), neutrophil (b), lymphocyte (c) and total white cell (d) numbers were determined. Data (n = 8) expressed as mean cell number (103/ml) ± S.E.M. *p < 0.05 vs. relevant saline-challenged controls, Mann-Whitney U-test. #p < 0.05 vs. challenged WT controls, Mann-Whitney U-test