Table 3 Plasticity of differentiated cells
From: Regeneration of the lung: Lung stem cells and the development of lung mimicking devices
Cell type | Marker genes | Differentiation potential | Signaling Cues |
|---|---|---|---|
Club cells | Scgb1a1+, Cyp2f2+ | Basal | Hippo pathway [44] |
| Â | Â | Ciliated | Unknown |
| Â | Â | Goblet | IL-13 exposure [169] |
AT-I | Hopx | AT-II | Modulated by TGF-β signaling [49] |
| Â | Â | Â | Proximal cell fate by overexpressing Sox2 [51] |
AT-II cells | Sftpc+, LysM | Proximal cells | Ectopic Sox2 expression [50] |
Ciliated cells | TubIVa, Foxj1 | Goblet | IL-13 exposure [47] |