Regeneration of the lung: Lung stem cells and the development of lung mimicking devices

Respiratory Research

Table 1 Overview basal-like stem cell populations

Cell type	Subtypes	Differentiation potential	Signaling Cues
(Tracheal) Basal Stem Cells	Trp63, Krt5, Krt14^+/−	Self-Renewal	Notch [25], Hippo signaling [44]
	Trp63, Krt5, Krt8	Basal Luminal Precursor Cell	Notch 3 signaling [16], Grhl2 [24]
		Neuroendocrine	Notch1 [164, 165] and Hes1 [166]
	Trp63, Krt5, N2ICD	Club	Notch^high signaling [15], Notch1 [167], Notch2 [164]
	Trp63, Krt5, c-Myb/Trp73	Ciliated	Notch^low signaling [15], Notch 1 and 2 [164]
Distal Alveolar Stem Cells ^a	Trp63, Krt5	Self-Renewal	Increased Notch activity, Notch1 [31]
		AT-II	Inhibition of Notch [31]
		Club

^aOnly observed after H1N1 influenza virus infection or bleomycin induced injury, AT-II Alveolar Type II Cells

ISSN: 1465-993X