Fig. 6
From: Protein tyrosine phosphatase PTP-RR regulates corticosteroid sensitivity
Proposal mechanism of regulation of corticosteroid sensitivity. Reduction of GR nuclear translocation by phosphorylation of GR-Ser226 is one of key mechanisms of corticosteroid insensitivity. Severe allergic inflammation associated with production of IL-2 and IL-4 (white arrows) induces phosphorylation of GR-Ser226 by JNK1 activation and PP2A inactivation (Tyr307 phosphorylation). PTP-RR regulates corticosteroid sensitivity by dephosphorylation of JNK1/GR-Ser226 directly and/or indirectly via PP2A