Fig. 3

Kaplan-Meier curves exploring the cut-off level of cFLC which relates to death. Kaplan-Meier survival curves according to cFLC levels in the A1ATD and usual COPD cohorts, solid lines representing those with levels below the specified threshold and dotted lines those with a level above it. A1ATD cohort ≥43.3 mg/L (n = 33), <43.3 mg/L (n = 507), ≥65 mg/L (n = 7), <65 mg/L (n = 533). Usual COPD cohort ≥43.3 mg/L (n = 79), <43.3 mg/L (n = 237), ≥65 mg/L (n = 24), <65 mg/L (n = 292). Please note the differing time scales, due to longer duration of follow up in A1ATD. All statistics are by log-rank test, and plots are unadjusted for covariates. A1ATD a Threshold of normal range (43.3 mg/L) p = 0.001 c Threshold ≥65 mg/L p <0.001. Usual COPD b Threshold of normal range p = 0.013 d Threshold ≥65 mg/L p = 0.012