Fig. 5
From: Diet-induced obesity alters myeloid cell populations in naïve and injured lung
Chemokine gradients and inflammatory gene expression in LFD and HFD mice. The plasma and broncho-alveolar fluid from LPS-challenged LFD and HFD mice were analyzed for chemokine levels at 24 h. a-c CXCL1, CXCL2, and CCL2 levels in BAL from LPS-treated mice were similar in HFD and LFD mice. d, e CXCL1 but not CXCL2 was significantly increased in the plasma from LPS-treated HFD vs. LFD mice. f BAL cells were isolated at 24 h post-LPS, and mRNA assessed for gene expression using qRT-PCR. Data are expressed as a ratio of expression, HFD/LFD, and a ratio of 1 highlighted by the dashed line. Il6 and Arg1 expression was reduced in HFD mice. Retnla expression was increased in HFD mice, and Tnfa, Nos2, Il12, Il10 were similarly expressed. *p value < 0.05; mean ± SEM (n = 7-10 mice/group)