Table 1 Characteristics of patients and controls at inclusion
All (IPAH + CTEPH) (n = 92) | IPAH (n = 42) | CTEPH (n = 50) | Healthy controls (n = 13) | P-value* | P-value** | |
|---|---|---|---|---|---|---|
Age (years) | 59 ± 17 | 49 ± 17 | 68 ± 12 | 46 ± 16 | <0.01 | 0.010 |
Female (%) | 54 | 67 | 44 | 54 | 0.030 | 0.973 |
Body mass index (kg/m2) | 27 ± 6 | 28 ± 7 | 26 ± 5 | 23 ± 3 | 0.259 | 0.009 |
NYHA II/III/IV (n) | 0/10/76/6 | 0/7/33/2 | 0/3/43/4 | n.a. | n.a. | n.a. |
6 min walking distance (m) | 330 ± 122 | 350 ± 115 | 314 ± 126 | n.a | 0.165 | n.a. |
Right atrial pressure (mmHg) | 7 ± 5 | 8 ± 5 | 5 ± 4 | n.a | 0.004 | n.a. |
Mean pulmonary artery pressure (mmHg) | 47 ± 14 | 53 ± 14 | 41 ± 10 | n.a | <0.01 | n.a. |
Pulmonary arterial wedge pressure (mmHg) | 8 ± 3 | 8 ± 3 | 8 ± 3 | 10 | 0.638 | n.a. |
Cardiac output (L/min) | 4.3 ± 1.2 | 4.3 ± 1.4 | 4.4 ± 1.2 | n.a | 0.733 | n.a. |
Cardiac index (L/min/m2) | 2.3 ± 0.6 | 2.3 ± 0.7 | 2.3 ± 0.5 | n.a | 0.955 | n.a. |
Pulmonary vascular resistance (dyn · s · cm−5) | 802 ± 416 | 970 ± 455 | 661 ± 321 | n.a | <0.01 | n.a. |
Mixed venous oxygen saturation (%) | 63 ± 7 | 63 ± 8 | 63 ± 6 | n.a | 0.991 | n.a. |
CXCL13 (pg/ml) | 120 ± 124 | 122 ± 127 | 118 ± 124 | 42 ± 15 | 0.858 | 0.026 |
CXCL13 (pg/ml) Median (IQR) | 83 (55,114) | 81 (64,113) | 84 (51,120) | 40 (28,48) | 0.597*** | <0.001*** |
CRP (mg/l) | 9 ± 15 | 8 ± 10 | 10 ± 17 | n.a | 0.583 | n.a. |
S-Sodium (mmol/l) | 140 ± 3 | 140 ± 3 | 140 ± 3 | n.a | 0.259 | n.a. |
NT-proBNP (ng/l) | 2,530 ± 2,222 | 2,761 ± 2,165 | 2,333 ± 2,278 | n.a | 0.412 | n.a. |
NT-proBNP (ng/l) Median, IQR | 1,929 (802–3,413) | 1,995 (1,276-4,010) | 1,747 (658–3,257) | n.a | 0.222*** | n.a. |
Bilirubin (μmol/l) | 15 ± 9 | 17 ± 9 | 14 ± 9 | n.a | 0.069 | n.a. |
Uric acid (μmol/l) | 411 ± 154 | 415 ± 142 | 407 ± 167 | n.a | 0.876 | n.a. |
Creatinine (μmol/l) | 90 ± 24 | 85 ± 26 | 94 ± 22 | n.a | 0.076 | n.a. |
eGFR ml/min/1,73 m2 | 75 ± 26 | 83 ± 31 | 69 ± 18 | n.a | 0.008 | n.a. |