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Table 1 Characteristics of patients and controls at inclusion

From: CXCL13 in idiopathic pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension

  All (IPAH + CTEPH) (n = 92) IPAH (n = 42) CTEPH (n = 50) Healthy controls (n = 13) P-value* P-value**
Age (years) 59 ± 17 49 ± 17 68 ± 12 46 ± 16 <0.01 0.010
Female (%) 54 67 44 54 0.030 0.973
Body mass index (kg/m2) 27 ± 6 28 ± 7 26 ± 5 23 ± 3 0.259 0.009
NYHA II/III/IV (n) 0/10/76/6 0/7/33/2 0/3/43/4 n.a. n.a. n.a.
6 min walking distance (m) 330 ± 122 350 ± 115 314 ± 126 n.a 0.165 n.a.
Right atrial pressure (mmHg) 7 ± 5 8 ± 5 5 ± 4 n.a 0.004 n.a.
Mean pulmonary artery pressure (mmHg) 47 ± 14 53 ± 14 41 ± 10 n.a <0.01 n.a.
Pulmonary arterial wedge pressure (mmHg) 8 ± 3 8 ± 3 8 ± 3 10 0.638 n.a.
Cardiac output (L/min) 4.3 ± 1.2 4.3 ± 1.4 4.4 ± 1.2 n.a 0.733 n.a.
Cardiac index (L/min/m2) 2.3 ± 0.6 2.3 ± 0.7 2.3 ± 0.5 n.a 0.955 n.a.
Pulmonary vascular resistance (dyn · s · cm−5) 802 ± 416 970 ± 455 661 ± 321 n.a <0.01 n.a.
Mixed venous oxygen saturation (%) 63 ± 7 63 ± 8 63 ± 6 n.a 0.991 n.a.
CXCL13 (pg/ml) 120 ± 124 122 ± 127 118 ± 124 42 ± 15 0.858 0.026
CXCL13 (pg/ml) Median (IQR) 83 (55,114) 81 (64,113) 84 (51,120) 40 (28,48) 0.597*** <0.001***
CRP (mg/l) 9 ± 15 8 ± 10 10 ± 17 n.a 0.583 n.a.
S-Sodium (mmol/l) 140 ± 3 140 ± 3 140 ± 3 n.a 0.259 n.a.
NT-proBNP (ng/l) 2,530 ± 2,222 2,761 ± 2,165 2,333 ± 2,278 n.a 0.412 n.a.
NT-proBNP (ng/l) Median, IQR 1,929 (802–3,413) 1,995 (1,276-4,010) 1,747 (658–3,257) n.a 0.222*** n.a.
Bilirubin (μmol/l) 15 ± 9 17 ± 9 14 ± 9 n.a 0.069 n.a.
Uric acid (μmol/l) 411 ± 154 415 ± 142 407 ± 167 n.a 0.876 n.a.
Creatinine (μmol/l) 90 ± 24 85 ± 26 94 ± 22 n.a 0.076 n.a.
eGFR ml/min/1,73 m2 75 ± 26 83 ± 31 69 ± 18 n.a 0.008 n.a.
  1. *IPAH vs. CTEPH, **IPAH and CTEPH combined versus controls
  2. n.a. not available, ***Mann-Whitney U-test