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Table 3 Baseline characteristics of patients in each enrolled trial

From: Can roflumilast, a phosphodiesterase-4 inhibitor, improve clinical outcomes in patients with moderate-to-severe chronic obstructive pulmonary disease? A meta-analysis

Author (year)

No.a

Age (year, SD)a

Sex (Male, %)a

BMI (kg/m2, SD)a

Smoking (Pack-year, SD)a

Post-FEV1/FVC (%, SD)a

Post-FEV1 (L, SD)a

Post-FEV1 (%predicted, SD)a

Post-FVC (L, SD)a

Bredenbroker, 2002

169

NM

NM

NM

NM

NM

NM

NM

NM

Boszormenyi-Nagy, 2005

200

NM

NM

NM

NM

NM

NM

NM

NM

Rabe, 2005

555

64 (42 ~ 87)

410 (75)

26 (5.0)

41 (20.6)

50 (12)

1.50 (0.48)

54 (13.2)

3.08 (0.85)

Calverley, 2007

760

65 (9.6)

571 (75)

25 (5.0)

42 (22.9)

40.3 (11.2)

1.13 (0.04)

41 (11.0)

NM

Calverley, 2009

1537

64 (9)

1150 (75)

25.8 (5.9)

48 (25)

42.3 (11.2)

1.10 (0.4)

36.1 (10.6)

NM

Fabbri, 2009

M2-127

466

65 (9)

319 (68)

NM

43 (22)

49.8 (9.4)

1.51 (0.4)

54.7 (9.1)

NM

M2-128

371

64 (9)

262 (71)

NM

43 (22)

52.7 (10.3)

1.55 (0.5)

56.0 (11.6)

NM

Lee, 2011

203

68 (41 ~ 91)

188 (92.6)

22.39 (3.7)

42 (22.1)

50.5 (11.8)

1.41 (0.5)

55.1 (16.5)

NM

Rennard, 2011 (M2-111)

567

64 (8.7)

387 (68.3)

26.0 (5.7)

50 (28.2)

43.3 (10.1)

1.12 (0.4)

36.8 (10.7)

NM

Ferguson, 2012

1150

NM

NM

NM

NM

NM

NM

NM

NM

O’Donnell, 2012

127

60 (9)

93 (73.2)

26.4 (5.0)

41 (20)

51 (11)

NM

56 (12)

NM

Zheng, 2014

313

64.2 (8.76)

283 (90.4)

21.8 (3.42)

37.2 (21.18)

35.78 (9.69)

0.95 (0.35)

36.84 (11.42)

NM

Martinez, 2015

969

65 (8.4)

718 (74)

26.5 (5.47)

48 (24.6)

40.2 (10.81)

1.1 (0.33)

35.4 (9.25)

NM

Wells, 2015

11

62 (7)

7 (64)

NM

47 (26)

53 (12)

NM

45 (12)

NM

  1. aData reported in all patients receiving vitamin D supplementation
  2. BMI body mass index, FEV 1 forced expiratory volume in one second, FVC forced vital capacity, NM not mentioned, No. numbers, SD standard derivation