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Fig. 4 | Respiratory Research

Fig. 4

From: Combination therapy of tiotropium and ciclesonide attenuates airway inflammation and remodeling in a guinea pig model of chronic asthma

Fig. 4

Airway smooth muscle mass thickening in response to chronic ovalbumin (OVA) challenge and treatment with saline (sal, control), tiotropium (tio; 0.01 and 0.03 mM; nebulizer concentration) or ciclesonide (cicl; 0.01 and 0.1 mg/kg). Guinea pigs were treated as described in Fig. 1b. Lungs were collected 24 h after the last OVA challenge and airway smooth muscle mass was determined by α-sm-myosin antibody staining of non-cartilaginous (a) and cartilaginous airways (b). * p < 0.05. Data represent mean ± s.e.m. of 4 animals per group

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