IL-25 and IL-33 induce Type 2 inflammation in basophils from subjects with allergic asthma

Respiratory Research

Table 2 Allergen inhalation induces airway inflammation in mild allergic asthmatics. Sputum cell count was measured pre and post-challenge to determine effect of allergen compared to diluent. Data are presented as mean ± SEM

	Pre-Diluent Challenge	7 h-Post Diluent Challenge	24 h-Post Diluent Challenge	Pre-Allergen Challenge	7 h-Post Allergen Challenge	24 h-Post Allergen Challenge
Sputum Total Cell Count (×10⁴ cells/mL)	1.7 ± 1.2	1.5 ± 0.9	1.5 ± 0.8	1.8 ± 1.2	3.4 ± 2.9	3.1 ± 2.3^a
Neutrophils (×10⁴ cells/mL)	1.0 ± 1.3	1.2 ± 1.3	1.3 ± 1.4	0.9 ± 0.9	2.4 ± 2.3^a	1.7 ± 1.3
Eosinophils (×10⁴ cells/mL)	0.01 ± 0.0	0.02 ± 0.0	0.006 ± 0.0	0.02 ± 0.0	0.3 ± 0.4^a	0.3 ± 0.4^a
Metachromatic cells (×10⁴ cells/mL)	0 ± 0.0	0 ± 0.0	0 ± 0.0	0.01 ± 0.0	0.2 ± 0.3^a	0.2 ± 0.2^a

ISSN: 1465-993X