Fig. 1

Allergen-inhalation induces changes in surface receptor expression for alarmin cytokines on basophils of mild allergic asthmatics. Percent of basophils expressing ST2, IL-17RB and intracellular IL-25 in 10 mild allergic asthmatics was measured in (a) bone marrow, (b) peripheral blood and (c) sputum at pre-allergen, 7 h and 24 h post-allergen (black symbols), compared to diluent (open symbols). Data are presented as median ± range. *Significantly different from pre-challenge for bone marrow and corresponding diluent-control time-point for peripheral blood and sputum, † significantly different from 0 h; P < 0.05 (N = 10)