Skip to main content
Fig. 4 | Respiratory Research

Fig. 4

From: Regulation of transforming growth factor-beta1 (TGF-β1)-induced pro-fibrotic activities by circadian clock gene BMAL1

Fig. 4

Effect of BMAL1 on TGF-β1-induced FMD. NHLFs were transiently transfected with siBMAL1 or control siRNA (siCtrl) for 48 h. During the last 24 h of transfection, the cells were treated with TGF-β1 at 1 ng/ml. Real-time qRT-PCR analysis was employed to investigate the expression of α-SMA (a) and PAI1 (b), * p < 0.05 vs. siCtrl-NT; ** p < 0.05 vs. siCtrl-TGF-β1. c Western blot analysis was carried out to investigate the TGF-β1-induced α-SMA, PAI1 and col-1 expression in response to BMAL1 knockdown. Densitometry analysis by ImageJ is presented. * p < 0.05 vs. corresponding control siRNA groups stimulated with TGF-β1 (siCtrl-TGF-β1)

Back to article page

Respiratory Research

ISSN: 1465-993X

Contact us