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Fig. 10 | Respiratory Research

Fig. 10

From: Regulation of transforming growth factor-beta1 (TGF-β1)-induced pro-fibrotic activities by circadian clock gene BMAL1

Fig. 10

Involvement of GSK3β in the regulation of BMAL1 on TGF-β1-induced Smad3 activation. a A549 cells transfected with siBMAL1 or control siRNA for 48 h and treated with TGF-β1 for another 8 h. The levels of phosphorylated (at Ser9) and total GSK3β were detected with specific antibodies. * p < 0.05 vs. corresponding control siRNA groups stimulated with TGF-β1 (siCtrl-TGF-β1). b A549 cells transfected with siBMAL1 or siCtrl for 48 h were pretreated with GSK3β inhibitors, LiCl or SB216763, for two and a half hours and then treated with TGF-β1 for another 30 min. The levels of phosphorylated and total Smad3 were detected with specific antibodies

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Respiratory Research

ISSN: 1465-993X

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