Association between pulmonary function and peak oxygen uptake in elderly: the Generation 100 study

Respiratory Research

Table 3 Explained variance of VO_2peak (Adjusted R²) of models with and without change points

Added variable	Hockey-stick model	Linear model	Curvilinear model
Men:
FEV₁	0.433*	0.423	0.429*
D_LCO	0.450*	0.440	0.451*
D_LCO/VA	0.440	0.441	0.441
Women:
FEV₁	0.460*	0.452	0.456*
D_LCO	0.470	0.469	0.470
D_LCO/VA	0.477	0.476	0.477

Definition of abbreviations: VO_2peak = peak oxygen uptake; FEV₁ = forced expiratory volume in 1 s; D_LCO – diffusing capacity of the lung for carbon monoxide; D_LCO/VA – D_LCO corrected for estimated alveolar volume. Resulting explained variance (Adjusted R²) of regression models with peak oxygen uptake as dependent variable with variable in first column added either as a variable with change point, as a linear variable or as a curvilinear variable (both variable and variable²). Age, self-reported physical activity, resting heart rate, body-fat percentage, self-reported history of heart disease and current smoking status are control variables in all models. *P-value < 0.05 for R²-change compared to linear model (f-test). Adjusted R² for VO_2peak in a multiple linear model without pulmonary function measurements, including only age, physical activity index, resting heart rate, body-fat percentage, smoking status and heart disease history were 0.393 for men and 0.448 for women

ISSN: 1465-993X