Medical and pharmacological approach to adjust the salbutamol anti-doping policy in athletes

Respiratory Research

Table 1 Published studies on the pharmacokinetics of inhaled salbutamol (updated on the 31st July 2014)

	Physical activity	Asthmatic status	Salbutamol inhaled dose	Rest or exercise	Exercise intensity	Sample size
Anderson 1998 [26]	Untrained	Healthy	1 × 180 μg	Rest		10
Berges 2000 [11]	Trained	Asthmatic	1 × 200 μg	Rest		15
Berges 2000 [11]	Trained	Healthy	4 × 400 μg	Rest		17
Pichon 2006 [27]	Trained	Healthy	3 × 200 μg	Rest		10
Sporer 2008 (1) [28]	Trained	Healthy	1 × 200 μg	Exercise (and Rest)	Cycling time	30
			and 1 × 400 μg
			and 1 × 800 μg
Sporer 2008 (2) [29]	Untrained	Healthy	1 × 200 μg	Rest		8
Elers 2010 [30]	Untrained	Asthmatic	1 × 200 μg	Rest		10
Elers 2011 [31]	Untrained	Asthmatic	4 × 400 μg	Rest		10
Elers 2011 [31]		Healthy				10
Elers 2012 [19]	Trained	Asthmatic	1 × 800 μg	Rest		10
Elers 2012 [19]	Trained	Healthy	1 × 800 μg	Rest		10
Dickinson 2014 [9]	Trained	Healthy	1 × 800 μg	Exercise (and Rest)	Not specified	32
Dickinson 2014 [9]	Trained	Healthy	and 1 × 1600 μg	Exercise (and Rest)	Not specified	32
Theoretical “Link-field study”	Trained	Asthmatic	Preventive dose: 3 × 200 μg	Exercise (and Rest)	Exercise	Powerful

Bold data identify conditions that we consider as optimal based on a rigorous clinical and scientific approach

ISSN: 1465-993X