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Fig. 4 | Respiratory Research

Fig. 4

From: RNA interference targeting carbohydrate sulfotransferase 3 diminishes macrophage accumulation, inhibits MMP-9 expression and promotes lung recovery in murine pulmonary emphysema

Fig. 4

Immunohistochemical detection of CSPGs and Glycosaminoglycans (GAGs) content on days 21 after PPE administration. a CS-56 recognizes an epitope on intact chondroitin sulfate glycosaminoglycan chains. CS-56 immunolabeling indicated that CHST3 siRNA treatment suppressed the increased chondroitin sulfate after PPE administration. b 3B3 recognizes an epitope created following the degradation of chondroitin-6 sulfate by ChABC. 3B3 immunolabeling indicated that CHST3 siRNA treatment suppressed the increased chondroitin-6 sulfate after PPE administration. Boxes indicate CS-56 or 3B3 staining in alveolar walls. Inserts show high magnification of boxes. Scale bar 100 μm. c GAGs content of the left lung on day 21 after PPE administration. (n = 5 per group). Mean ± SD, *p < 0.01 versus the Sham group. † p < 0.01 versus the Control siRNA group

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Respiratory Research

ISSN: 1465-993X

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