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Fig. 3 | Respiratory Research

Fig. 3

From: Prostaglandin E2 stimulates normal bronchial epithelial cell growth through induction of c-Jun and PDK1, a kinase implicated in oncogenesis

Fig. 3

c-Jun Mediates the Cell Proliferation and increased expression and activation of PDK1 induced by PGE2 in HBEc14-KT and BEAS2B cells. a dmPGE2 increases expression of c-Jun in a time- and dose-dependent manner in BEAS2B and HBEc14-KT cells. b c-Jun siRNA decreases the cell proliferation induced by dmPGE2 in normal bronchial epithelial cells. c c-Jun plasmid increases the cell proliferation induced by dmPGE2 in normal bronchial epithelial cells. d c-Jun siRNA decreases expression of PDK1 induced by dmPGE2 in BEAS2B and HBEc14-KT cells. e c-Jun plasmid increases expression of PDK1 induced by dmPGE2 in BEAS2B and HBEc14-KT cells. f Effect of c-Jun siRNA on PDK1 promoter activity. g Effect of c-Jun plasmid on PDK1 promoter activity. h Effects of c-Jun point-moutations on PDK1 promoter activity

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Respiratory Research

ISSN: 1465-993X

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