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Fig. 1 | Respiratory Research

Fig. 1

From: Prostaglandin E2 stimulates normal bronchial epithelial cell growth through induction of c-Jun and PDK1, a kinase implicated in oncogenesis

Fig. 1

The effect of dmPGE2 on human bronchial epithelial cell proliferation and induction of expression and activation of PDK1. a Effects on cell proliferation. b dmPGE2 increases the phosphorylation and expression of PDK1 in a time- and dose-dependent manner in BEAS2B and HBEc14-KT cells. c PDK1 inhibitor OSU-03012 decreases cell proliferation induced by dmPGE2 in normal bronchial epithelial cells. d PDK1 siRNA decreases the cell proliferation induced by dmPGE2 in normal bronchial epithelial cells. e PDK1 plasmid increases the cell proliferation induced by dmPGE2 in normal bronchial epithelial cells. f Effect on mRNA expression. g Effect on PDK1 promoter activity

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Respiratory Research

ISSN: 1465-993X

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