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Table 3 Correlation between HNPs and IL-8 and clinical parameters in patients with SSc-ILD

From: Association of elevated α-defensin levels with interstitial pneumonia in patients with systemic sclerosis

Variables

 

HNPs in BALF

IL-8 in BALF

 

N

r

95 % CI

P-value

r

95 % CI

P-value

HNPs in plasma

33

0.049

−0.299 – 0.386

0.79

−0.06

−0.395 – 0.289

0.75

HNPs in BALF

33

0.774

0.587 – 0.883

<0.01

IL-8 in serum

33

0.324

−0.022 – 0.600

0.07

0.160

−0.194 – 0.477

0.38

IL-8 in BALF

33

0.774

0.587 – 0.883

<0.01

Laboratory data

 PaO2 (torr)

28

−0.416

−0.683 – −0.051

0.03

−0.429

−0.691 – −0.067

0.02

 KL-6 (U/mL)

30

0.511

0.185 – 0.736

<0.01

0.467

0.128 – 0.708

<0.01

 SP-D (ng/mL)

33

0.363

0.023 – 0.628

0.04

0.360

0.019 – 0.626

0.04

 SP-A (ng/mL)

25

0.256

−0.155 – 0.591

0.23

0.364

−0.36 – 0.664

0.08

Pulmonary function test

 %VC (%)

33

−0.575

−0.767 – −0.289

<0.01

−0.636

−0.804 – −0.374

<0.01

 FEV1/FEV (%)

33

0.106

−0.246 – 0.434

0.56

−0.091

−0.421 – 0.260

0.61

 %DLco (%)

32

−0.529

−0.741 – −0.221

<0.01

−0.492

−0.718 – −0.173

<0.01

BALF cell findings

 TCC (× 105/mL)

33

−0.036

−0.375 – 0.311

0.84

−0.065

−0.399 – 0.285

0.72

 Macrophages (%)

33

0.016

−0.329 – 0.357

0.93

−0.010

−0.352 – 0.335

0.96

 Lymphocytes (%)

33

−0.153

−0.472 – 0.201

0.40

−0.167

−0.483 – 0.187

0.35

 Neutrophils (%)

33

0.595

0.316 – 0.779

<0.01

0.540

0.242 – 0.745

<0.01

 Eosinophils (%)

33

0.466

0.146 – 0.698

<0.01

0.419

0.088 – 0.666

0.02

 CD4/8 (%)

33

−0.090

−0.420 – 0.261

0.62

−0.009

−0.351 – 0.335

0.96

HRCT findings

 Ground glass opacity (%)

33

0.711

0.486 – 0.848

<0.01

0.583

0.230 – 0.772

<0.01

 Reticular opacities (%)

33

0.652

0.398 – 0.813

<0.01

0.605

0.330 – 0.785

<0.01

TRPG

30

0.517

0.193 – 0.740

<0.01

0.473

0.136 – 0.712

<0.01

Decline in absolute VC (%)

 One year

15

−0.275

−0.690 – 0.276

0.32

−0.059

−0.555 – 0.467

0.84

 Two years

12

−0.070

−0.619 – 0.525

0.83

0.010

−0.567 – 0.581

0.97

  1. TRPG tricuspid regurgitation peak gradient