Mannose-binding lectin protein and its association to clinical outcomes in COPD: a longitudinal study

Respiratory Research

Table 3 Frequency of MBL2 haplotypes in relation to exacerbations

MBL2 Haplotype	Expected serum MBL Level	Infrequent exacerbation		Frequent exacerbation		p value
		n	Frequency	n	Frequency
HYPA	High	87	0.282	85	0.346	0.13
LYQA	High	75	0.243	53	0.215	0.49
LYPA	High	30	0.097	15	0.061	0.16
LXPA	Intermediate	71	0.230	50	0.203	0.50
LYPB	Low	27	0.087	19	0.077	0.77
HYPD	Low	10	0.032	21	0.085	0.01
LYQC	Low	8	0.026	3	0.012	0.39

The distribution of haplotypes corresponding to express high to low serum MBL are categorized in infrequent and frequent exacerbation. Here, the HYPD haplotype is significantly higher among frequent exacerbators

ISSN: 1465-993X